Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease …

Advanced glycation end products (AGEs) and their receptor have been implicated in the
progressions of many intractable diseases, such as diabetes and atherosclerosis, and are …

Advanced glycation endproducts (AGEs) form by Maillard-reactions after initial binding of
aldehydes with amines or amides in heated foods or in living organisms. The mechanisms of …

The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

Ferroptosis is a form of inflammatory cell death for which key mediators remain obscure.
Here, we report that the proteoglycan decorin (DCN) is released by cells that are dying from …

Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong
risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of …

The receptor for advanced glycation end-product (RAGE) is the signal transduction receptor
which senses a variety of signalling molecules including advanced glycation end products …

Innate immune receptors for pathogen-and damage-associated molecular patterns (PAMPs
and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by …

High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that
exerts divergent biological tasks inside and outside of cells. The functions of HMGB1 …

ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …