Many research questions in fields such as personalized medicine, drug screens or systems
biology depend on obtaining consistent and quantitatively accurate proteomics data from …

Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …

Quantitative phosphoproteomics has transformed investigations of cell signaling, but it
remains challenging to scale the technology for high-throughput analyses. Here we report a …

Comprehensive, reproducible and precise analysis of large sample cohorts is one of the key
objectives of quantitative proteomics. Here, we present an implementation of data …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR)
and AMP-activated protein kinase (AMPK) are central to cellular metabolism and cell …

Cytochrome c (Cytc) 1 is a cellular life and death decision molecule that regulates cellular
energy supply and apoptosis through tissue specific post-translational modifications. Cytc is …

Phosphoproteomics can provide insights into cellular signaling dynamics. To achieve deep
and robust quantitative phosphoproteomics profiling for minute amounts of sample, we here …

Recent advances in methodology have made phosphopeptide analysis a tractable problem
for many proteomics researchers. There are now a wide variety of robust and accessible …