Importance Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the
pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States …

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

A combination of genetic, environmental, and metabolic factors contribute to the
development and recurrence of acute and chronic pancreatitis; information on all of these is …

Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …

Objective Alcohol-related pancreatitis is associated with a disproportionately large number
of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility …

Hereditary pancreatitis (HP) is a rare cause of acute, recurrent acute, and chronic
pancreatitis. It may present similarly to other causes of acute and chronic pancreatitis, and …

Objectives: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been
diagnosed in children at increasing rates during the past decade. As pediatric ARP and CP …

BACKGROUND & AIMS: Premature activation of trypsinogen activation can cause
pancreatic injury and has been associated with chronic pancreatitis (CP). Mice that lack intra …