The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Significance: It has been proposed that cancer cells are heavily dependent on their
antioxidant defenses for survival and growth. Peroxiredoxins are a family of abundant thiol …

Proteinaceous cysteines function as essential sensors of cellular redox state. Consequently,
defining the cysteine redoxome is a key challenge for functional proteomic studies. While …

Peroxiredoxins are central to cellular redox homeostasis and signaling. They serve as
peroxide scavengers, sensors, signal transducers, and chaperones, depending on …

The bacterial thiopeptide thiostrepton (TS) is used as a veterinary medicine to treat bacterial
infections. TS is a protein translation inhibitor, essentially active against Gram-positive …

Peroxiredoxins (Prxs), a family of peroxidases, are reactive oxygen species scavengers that
hydrolyze H2O2 through catalytic cysteine. Mammalian Prxs comprise six isoforms (typical 2 …

Cell death pathways such as apoptosis can be activated in response to oxidative stress,
enabling the disposal of damaged cells. In contrast, controlled intracellular redox events are …

Peroxiredoxins have a long-established cellular function as regulators of redox metabolism
by catalyzing the reduction of peroxides (eg, H2O2, lipid peroxides) with high catalytic …

Peroxiredoxins (PRDXs) catalyze the reduction of hydrogen peroxide (H 2 O 2). PRDX4 is
the only peroxiredoxin located within the endoplasmic reticulum (ER) and is the most highly …

Malignant pleural mesothelioma (MPM) is a rare malignancy of mesothelial cells with
increasing incidence, and in many cases, dismal prognosis due to its aggressiveness and …