Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

Twenty‐five genome‐wide association studies (GWAS) of asthma were published between
2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies …

Congenital heart diseases often involve maldevelopment of the evolutionarily recent right
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …

Vesicular transport relies on multimeric trafficking complexes to capture cargo and drive
vesicle budding and fusion. Faithful assembly of the trafficking complexes is essential to …

Adaptor protein (AP) complexes are evolutionarily conserved vesicle transport regulators
that recruit coat proteins, membrane cargoes and coated vesicle accessory proteins. As in …

Protein coats are supramolecular complexes that assemble on the cytosolic face of
membranes to promote cargo sorting and transport carrier formation in the endomembrane …

The term palmoplantar keratoderma (PPK) indicates any form of persistent thickening of the
epidermis of palms and soles and includes genetic as well as acquired conditions. We …

Hereditary palmoplantar keratoderma (PPK) is a heterogeneous group of disorders
characterized by hyperkeratosis of the palm and the sole skin. Hereditary PPK are divided …

Multimeric adaptors are broadly involved in vesicle-mediated membrane trafficking. AP2
adaptor, in particular, plays a central role in clathrin-mediated endocytosis (CME) by …

Background Neoadjuvant chemotherapy is increasingly given preoperatively to shrink
breast tumours prior to surgery. This approach also provides the opportunity to study the …