Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …

Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

The heart is the first organ formed during mammalian development. A properly sized and
functional heart is vital throughout the entire lifespan. Loss of cardiomyocytes because of …

Heart malformations are common congenital defects in humans. Many congenital heart
defects involve anomalies in cardiac septation or valve development, and understanding the …

The myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized …

Abstract Purpose of Review Cardiovascular diseases are the leading cause of death
worldwide, largely due to the limited regenerative capacity of the adult human heart. In …