Update on the Association of Inflammation and Atrial Fibrillation. Atrial fibrillation (AF) is a
common arrhythmia and is associated with significant morbidity and mortality. The …

Influx of Ca2+ through L-type Ca2+ channels (LTCCs) contributes to numerous cellular
processes in cardiomyocytes including excitation–contraction (EC) coupling, membrane …

Background—Pitx2 is a homeobox transcription factor that plays a pivotal role in early
left/right determination during embryonic development. Pitx2 loss-of-function mouse mutants …

Aims Increasing evidence supports a role for inflammation in promoting atrial fibrillation (AF)
and statins have anti-inflammatory effects that may be relevant for the prevention of AF …

Rationale: The cardiac inwardly rectifying K+ current (I K1) plays a critical role in modulating
excitability by setting the resting membrane potential and shaping phase 3 of the cardiac …

Atrial fibrillation (AF) is the most common sustained arrhythmia. Anti-arrhythmic drugs
remain the mainstay of therapy, but the available class I and III anti-arrhythmic drugs are …

Cardiac arrhythmias are a leading cause of morbidity and mortality in the Western world.
Ventricular arrhythmias are reportedly responsible for the majority of sudden cardiac deaths …

Efforts to identify the mechanisms for the initiation and maintenance of human atrial
fibrillation (AF) often focus on changes in specific elements of the atrial “substrate,” ie, its …

The advent of statins has revolutionised the treatment of patients with raised plasma
cholesterol and increased cardiovascular risk. However, the beneficial effects of this class of …

Aims Endocannabinoids are synthesized from lipid precursors at the plasma membranes of
virtually all cell types, including cardiac myocytes. Endocannabinoids can modulate …