Morin is a natural polyphenol, originally isolated from members of the Moraceae family that
can be extracted from leaves, fruits, stems and branches of numerous plants. Several …

The present article aims to review the up-to-date information on the most recent studies of
the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic …

Probenecid is a well-established drug for the treatment of gout and is thought to act on an
organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking …

Flavonoids represent polyphenolic plant secondary metabolites with a general structure of a
15-carbon skeleton comprising two phenyl rings and a heterocyclic ring. Over 5000 natural …

Our previous studies had reported that morin, a bioflavanoid exhibited potent anti-
inflammatory effect against adjuvant-induced arthritic rats. In this current study, we …

Background and purpose: The xanthine oxidase inhibitors allopurinol and oxypurinol are
used to treat hyperuricaemia, whereas loop and thiazide diuretics can cause iatrogenic …

The aim of this study was to investigate the effects of onion on serum uric acid levels and
hepatic Xanthine Dehydrogenase/Xanthine Oxidase activities in normal and hyperuricemic …

Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the
uric acid transporter, URAT1. We exploited affinity differences between the human and rat …

In the present study, a natural product database of compounds associated with herbs
traditionally verified to treat gout/hyperuricemia/arthritis was constructed. 3D-shape and …

Previously we discovered a novel natural scaffold compound, isobavachin (4′, 7-dihydroxy-
8-prenylflavanone), as a potent URAT1 inhibitor by shape and structure based on a virtue …