A hallmark of cancer cells includes a metabolic reprograming that provides energy, the
essential building blocks, and signaling required to maintain survival, rapid growth …

Drug repurposing is a strategy consisting of finding new indications for already known
marketed drugs used in various clinical settings or highly characterized compounds despite …

Over the last years, repurposed agents have provided growing evidence of fast
implementation in oncology treatment such as certain antimalarial, anthelmintic, antibiotics …

High-density lipoproteins (HDL) are well known for their protective role against the
development and progression of atherosclerosis. Atheroprotection is mainly due to the key …

Background Statin use has been linked to a reduced risk of advanced colorectal adenomas,
but its association with colorectal cancer (CRC) in patients with inflammatory bowel disease …

Background Emerging data have suggested colorectal cancer (CRC) often coexists with
cardiovascular diseases, but whether cardiovascular risk factors play a role in CRC remains …

Background This study investigated the association between the use of statins, the
incidence of gastric, colorectal, and esophageal cancers, and mortality between January …

Inflammation is an essential defense mechanism in which innate immune cells are
coordinately activated on encounter of harmful stimuli, including pathogens, tissue injury …

METHODS: Eligible participants (100,300 women and 47,991 men) in the Nurses' Health
Study and Health Professionals Follow-Up Study were followed for up to 24 years. Cox …

Abstract Background Metabolic syndrome (MetS) is a worldwide pandemic and complex
disorder associated with colorectal cancer (CRC). This study aims to identify the influence of …