Diffuse glioma heterogeneity and its therapeutic implications
JG Nicholson, HA Fine - Cancer discovery, 2021 - AACR
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …
characterized by minimally effective genotype-targeted therapies. Recent advances have …
[HTML][HTML] TERT Promoter Alterations in Glioblastoma: A Systematic Review
N Olympios, V Gilard, F Marguet, F Clatot, F Di Fiore… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma is the most common malignant primary brain tumor in adults.
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …
Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells
M Vinci, A Burford, V Molinari, K Kessler, S Popov… - Nature medicine, 2018 - nature.com
The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse
intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to …
intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to …
[HTML][HTML] Regional identity of human neural stem cells determines oncogenic responses to histone H3. 3 mutants
RB Bressan, B Southgate, KM Ferguson, C Blin… - Cell Stem Cell, 2021 - cell.com
Point mutations within the histone H3. 3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …
High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts
Background Considering that pediatric high-grade gliomas (HGGs) are biologically distinct
from their adult counterparts, the objective of this study was to define the landscape of HGGs …
from their adult counterparts, the objective of this study was to define the landscape of HGGs …
[PDF][PDF] Brain tumors in neurofibromatosis type 1
ADA Costa, DH Gutmann - Neuro-Oncology Advances, 2020 - academic.oup.com
AbstractAs a cancer predisposition syndrome, individuals with neurofibromatosis type 1
(NF1) are at increased risk for the development of both benign and malignant tumors. One of …
(NF1) are at increased risk for the development of both benign and malignant tumors. One of …
[HTML][HTML] Addressing blood-brain-tumor-barrier heterogeneity in pediatric brain tumors with innovative preclinical models
EK Morris, S Daignault-Mill, SJ Stehbens… - Frontiers in …, 2023 - frontiersin.org
Brain tumors represent the leading cause of disease-related mortality and morbidity in
children, with effective treatments urgently required. One factor limiting the effectiveness of …
children, with effective treatments urgently required. One factor limiting the effectiveness of …
Targeting and therapeutic monitoring of H3K27M-mutant glioma
Abstract Purpose of Review H3K27M is a frequent histone mutation within diffuse midline
gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO …
gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS WHO …
[HTML][HTML] H3G34-mutant gliomas—a review of molecular pathogenesis and therapeutic options
The 2021 World Health Organization Classification of Tumors of the Central Nervous System
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …
reflected advances in understanding of the roles of oncohistones in gliomagenesis with the …
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
We analyzed the contributions of structural variants (SVs) to gliomagenesis across 179
pediatric high-grade gliomas (pHGGs). The most recurrent SVs targeted MYC isoforms and …
pediatric high-grade gliomas (pHGGs). The most recurrent SVs targeted MYC isoforms and …