T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

The invariant chain (CD74) is well known for its essential role in antigen presentation by
mediating assembly and subcellular trafficking of the MHCII complex. Beyond this, CD74 …

MHC class II molecules assemble in the endoplasmic reticulum in a chaperone-mediated
fashion to form a nine-chain structure consisting of three alpha beta dimers associated with …

T lymphocytes with~/~ receptors recognize antigen in association with the polymorphic
products of the class I and class II loci of the major histocompatibility complex (MHC). This …

For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in
association with major histocompatibility complex class II (MHCII) to naïve CD4+ T …

Dendritic cells (DCs) developmentally regulate their capacity for antigen presentation by
controlling the transport and surface expression of MHC class II molecules. These events …

Abstract HLA CLASS II molecules are heterodimeric transmembrane glycoproteins that bind
and present processed antigenic peptides to CD4-positive T lymphocytes. Intracellularly …

MAJOR histocompatibility complex class I molecules bind antigenic peptides in the
endoplasmic reticulum (ER) and transport them to the cell surface for recognition by …

Use of alternative initiator methionines in human invariant (Ii) chain mRNA results in the
synthesis of two polypeptides, Iip33 and Iip31. After synthesis both isoforms are inserted into …