ESX/type VII secretion systems and their role in host–pathogen interaction
R Simeone, D Bottai, R Brosch - Current opinion in microbiology, 2009 - Elsevier
The ESX-1 system is responsible for the secretion of the prototypic ESX proteins, namely the
6kDa early secreted antigenic target (ESAT-6) and the 10kDa culture filtrate protein (CFP …
6kDa early secreted antigenic target (ESAT-6) and the 10kDa culture filtrate protein (CFP …
Tuberculosis diagnosis using immunodominant, secreted antigens of Mycobacterium tuberculosis
Tuberculosis (TB) remains a major public health concern in most low-income countries.
Hence, rapid and sensitive TB diagnostics play an important role in detecting and preventing …
Hence, rapid and sensitive TB diagnostics play an important role in detecting and preventing …
Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
A Mehra, A Zahra, V Thompson… - PLoS …, 2013 - journals.plos.org
Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells
that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to …
that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to …
Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis
Mycobacterium tuberculosis ESAT-6 (MtbESAT-6) reportedly shows membrane/cell-lysis
activity, and recently its biological roles in pathogenesis have been implicated in rupture of …
activity, and recently its biological roles in pathogenesis have been implicated in rupture of …
WXG100 protein superfamily consists of three subfamilies and exhibits an α-helical C-terminal conserved residue pattern
C Poulsen, S Panjikar, SJ Holton, M Wilmanns… - PLoS …, 2014 - journals.plos.org
Members of the WXG100 protein superfamily form homo-or heterodimeric complexes. The
most studied proteins among them are the secreted T-cell antigens CFP-10 (10 kDa culture …
most studied proteins among them are the secreted T-cell antigens CFP-10 (10 kDa culture …
The ABCs and 123s of bacterial secretion systems in plant pathogenesis
JH Chang, D Desveaux… - Annual review of …, 2014 - annualreviews.org
Bacteria have many export and secretion systems that translocate cargo into and across
biological membranes. Seven secretion systems contribute to pathogenicity by translocating …
biological membranes. Seven secretion systems contribute to pathogenicity by translocating …
Mechanism of ESAT-6 membrane interaction and its roles in pathogenesis of Mycobacterium tuberculosis
X Peng, J Sun - Toxicon, 2016 - Elsevier
The 6-kDa early secreted antigenic target (ESAT-6; EsxA) of Mycobacterium tuberculosis
was first identified as a potent T-cell antigen, and it is now recognized as a pore-forming …
was first identified as a potent T-cell antigen, and it is now recognized as a pore-forming …
Solution structure of the Mycobacterium tuberculosis EsxG· EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes
Mycobacterium tuberculosis encodes five type VII secretion systems that are responsible for
exporting a number of proteins, including members of the Esx family, which have been …
exporting a number of proteins, including members of the Esx family, which have been …
Tubercle bacilli rely on a type VII army for pathogenicity
EJM Stoop, W Bitter, AM van der Sar - Trends in microbiology, 2012 - cell.com
Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a
highly unusual and characteristic diderm cell envelope that protects them against harmful …
highly unusual and characteristic diderm cell envelope that protects them against harmful …
Characterization of Mycobacterium tuberculosis EsxA membrane insertion: roles of N-and C-terminal flexible arms and central helix-turn-helix motif
Y Ma, V Keil, J Sun - Journal of Biological Chemistry, 2015 - ASBMB
EsxA (ESAT-6), an important virulence factor of Mycobacterium tuberculosis, plays an
essential role in phagosome rupture and bacterial cytosolic translocation within host …
essential role in phagosome rupture and bacterial cytosolic translocation within host …