Pirfenidone alleviates concanavalin A-induced liver fibrosis in mice

MM Salah, AA Ashour, TM Abdelghany… - Life sciences, 2019 - Elsevier
Aims Liver fibrosis (LF) is a life-threatening complication of most chronic liver diseases
resulting from a variety of injurious agents and hepatotoxic insults. To date, there are no …

Pristimerin as a novel hepatoprotective agent against experimental autoimmune hepatitis

DS El-Agamy, AA Shaaban, HH Almaramhy… - Frontiers in …, 2018 - frontiersin.org
Pristimerin (Pris) is bioactive natural quinonoid triterpene that has anti-inflammatory and anti-
cancer activities. Meanwhile, its effect against hepatitis needs to be elucidated. This …

[HTML][HTML] The effects of tadalafil and pentoxifylline on apoptosis and nitric oxide synthase in liver ischemia/reperfusion injury

S Bektas, K Karakaya, M Can, B Bahadir… - The Kaohsiung journal …, 2016 - Elsevier
The aim of this study was to investigate the effects of tadalafil (TDF) and pentoxifylline (PTX)
on hepatic apoptosis and the expressions of endothelial and inducible nitric oxide synthases …

Antifibrotic mechanism of deferoxamine in concanavalin A induced-liver fibrosis: Impact on interferon therapy

SF Darwish, WM El-Bakly, RN El-Naga… - Biochemical …, 2015 - Elsevier
Iron-overload is a well-known factor of hepatotoxicity and liver fibrosis, which found to be a
common finding among hepatitis C virus patients and related to interferon resistance. We …

Pentoxifylline attenuates cytokine stress and Fas system in syngeneic liver proteins induced experimental autoimmune hepatitis

N Hendawy - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Background Apoptosis is a hallmark in the pathogenesis of autoimmune hepatitis (AIH).
Cytokine stresses and extrinsic apoptotic pathway have been implicated in this type of …

[PDF][PDF] Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study

FR Mohammed, YMKAM Hummadi, MI Al-Ezzi - Pharmacia, 2024 - pharmacia.pensoft.net
Drug-induced liver injury (DILI) is a serious complication of many drugs, including
carbamazepine; this study investigates the protective effect of pentoxifylline (PTX) against …

Comparison of the effects of pentoxifylline, simvastatin, tamoxifen, and losartan on cavernous bodies after penile fracture in rats: a stereological study

A Eslahi, M Shirazi, O Khoshnood… - International Journal of …, 2020 - nature.com
Penile fracture (PF) is described as a rupture and fibrosis of the cavernous bodies. This
study aimed to collect quantitative data on the impacts of pentoxifylline, simvastatin …

Hepatoprotective activity of isostrictiniin from Nymphaea candida on Con A-induced acute liver injury in mice

J Zhao, M Tuersunmaimaiti, T Ji, T Liu… - Natural Product …, 2021 - Taylor & Francis
This study is to investigate hepatoprotective activity of isostrictiniin from Nymphaea candida.
Hepatic injury in mice was induced immunologically by caudal vein injecting Con A (20 …

[PDF][PDF] The effect of MDMA and pentoxifylline drug on bad/bcl-xl gene dosage expression changes on rat liver

M Behroozaghdam, M Hashemi… - … of Advances in …, 2015 - journals.sbmu.ac.ir
ABSTRACT MDMA generally known as ecstasy, have deleterious effects on the serotonergic
neurotransmitter system. Recent findings suggest that the liver and brain are major target …