NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …

Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …

Platinum complexes are widely used anticancer drugs. New generations of metal
chemotherapeutics offer the prospect of combating platinum resistance and expanding the …

Due to the increasing impact of cancer on worldwide mortality, more and more attention is
being devoted to the investigation of novel anticancer strategies. Among these …

Which elements are essential for human life? Here we make an element-by-element journey
through the periodic table and attempt to assess whether elements are essential or not, and …

Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as
hydrophobic properties due to the robustness of the ruthenium–arene unit hold a high …

Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4
(Im)(S-dmso)], where Im= imidazole and S-dmso= S-bound dimethylsulfoxide) or KP1019 …

Carbon monoxide (CO) is an endogenous small signalling molecule in the human body,
produced by the action of haem oxygenase on haem. Since it is very difficult to apply safely …

A great majority of the Ru complexes currently studied in anticancer research exert their
antiproliferative activity, at least partially, through ligand exchange. In recent years, however …