Potassium (K), the main cation inside cells, plays roles in maintaining cellular osmolarity and
acid–base equilibrium, as well as nerve stimulation transmission, and regulation of cardiac …

KCNMA1 encodes the pore-forming α subunit of the “Big K+”(BK) large conductance calcium
and voltage-activated K+ channel. BK channels are widely distributed across tissues …

Potassium disorders are common in patients with kidney disease, particularly in patients
with tubular disorders and low glomerular filtration rate. A multidisciplinary group of …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

Colonic epithelial cells are responsible for maintaining a delicate balance between luminal
secretion and the absorption of fluids and ions. This review aims to discuss and update the …

Enteroendocrine cells (EECs) are an essential interface between the gut and brain that
communicate signals about nutrients, pain, and even information from our microbiome …

The kidney is the major regulator of potassium homeostasis. In addition to the ROMK
channels, large conductance Ca 2+-activated K+(BK) channels are expressed in the apical …

Epithelial cells of the gastrointestinal tract are an important barrier between the “milieu
interne” and the luminal content of the gut. They perform transport of nutrients, salts, and …

Molecular mechanisms of prostate cancer progression are poorly understood. Here, we
studied gene amplification of the large conductance calcium-activated potassium channel …

Rotavirus infection is the most frequent cause for severe diarrhea in infants, killing more than
600,000 every year. The nonstructural protein NSP4 acts as a rotavirus enterotoxin, inducing …