The hypomethylating agent azacitidine can prolong overall survival (OS) in patients with higher risk-myelodysplastic syndromes (HR-MDS) compared to conventional regimens …
Myelodysplastic syndromes/neoplasms (MDS) are heterogeneous, clonal myeloid neoplasms characterized by ineffective hematopoiesis, progressive cytopenias, and an …
I Pessach, T Spyropoulos, E Lamprianidou… - Cancers, 2022 - mdpi.com
Simple Summary Measurable residual disease (MRD) is emerging as an important prognostic and predictive biomarker in acute myeloid leukemia (AML). However, its use is …
A Bouchla, SG Papageorgiou, A Symeonidis… - Leukemia, 2023 - nature.com
Higher-risk myelodysplastic syndromes (HR-MDS) are characterized by an increased risk of acute myeloid leukemia (AML) transformation and compromised overall survival (OS)[1, 2] …
A Bouchla, TP Thomopoulos, SG Papageorgiou… - …, 2021 - Taylor & Francis
5-Azacitidine (5-AZA) is widely used for the treatment of higher-risk myelodysplastic syndromes. However, response and survival rates vary considerably, while indicated …
EM Stein, G Bonifacio, D Latremouille-Viau… - Leukemia & …, 2021 - Taylor & Francis
To describe real-world treatment patterns and outcomes among adult patients with myelodysplastic syndromes (MDS) treated with hypomethylating agents (HMA), patients …
PT Diamantopoulos, NA Viniou - Leukemia research, 2021 - Elsevier
The introduction of hypomethylating agents (HMAs) 5-azacytidine and decitabine has altered the prognosis of patients with myelodysplastic syndrome (MDS). Over the past few …
MA Hospital, N Vey - Current Oncology Reports, 2020 - Springer
Abstract Purpose of Review To understand how myelodysplastic syndromes (MDS) transform to AML and to describe how transformation can be predicted and prevented …