Novel drug delivery systems and disease models for pulmonary fibrosis

R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …

A robust method for perfusable microvascular network formation in vitro

Z Wan, AX Zhong, S Zhang, G Pavlou… - Small …, 2022 - Wiley Online Library
Micropost‐based microfluidic devices are widely used for microvascular network (MVN)
formation in diverse research fields. However, consistently generating perfusable MVNs of …

[HTML][HTML] In Vitro Modeling of Idiopathic Pulmonary Fibrosis: Lung-on-a-Chip Systems and Other 3D Cultures

C Corona, K Man, CA Newton, KT Nguyen… - International Journal of …, 2024 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a lethal disorder characterized by relentless
progression of lung fibrosis that causes respiratory failure and early death. Currently, no …

Flow in fetoplacental-like microvessels in vitro enhances perfusion, barrier function, and matrix stability

M Cherubini, S Erickson, P Padmanaban… - Science …, 2023 - science.org
Proper placental vascularization is vital for pregnancy outcomes, but assessing it with
animal models and human explants has limitations. We introduce a 3D in vitro model of …

A biomimetic renal fibrosis progression model on-chip evaluates anti-fibrotic effects longitudinally in a dynamic fibrogenic niche

D Wu, J Wu, H Liu, S Shi, L Wang, Y Huang, X Yu… - Lab on a Chip, 2023 - pubs.rsc.org
Although renal fibrosis can advance chronic kidney disease and progressively lead to end-
stage renal failure, no effective anti-fibrotic drugs have been clinically approved. To aid drug …

Mammary microvessels are sensitive to menstrual cycle sex hormones

C Moccia, M Cherubini, M Fortea, A Akinbote… - Advanced …, 2023 - Wiley Online Library
The mammary gland is a highly vascularized organ influenced by sex hormones including
estrogen (E2) and progesterone (P4). Beyond whole‐organism studies in rodents or cell …

[HTML][HTML] Advancements in preclinical human-relevant modeling of pulmonary vasculature on-chip

Q Vo, KH Benam - European Journal of Pharmaceutical Sciences, 2024 - Elsevier
Preclinical human-relevant modeling of organ-specific vasculature offers a unique
opportunity to recreate pathophysiological intercellular, tissue-tissue, and cell-matrix …

Advances in the model structure of in vitro vascularized organ-on-a-chip

H Yin, Y Wang, N Liu, S Zhong, L Li… - Cyborg and Bionic …, 2024 - spj.science.org
Microvasculature plays a crucial role in human physiology and is closely related to various
human diseases. Building in vitro vascular networks is essential for studying vascular tissue …

3D matrix stiffness modulation unveils cardiac fibroblast phenotypic switching

Y Han, Z Shao, Y Zhang, H Zhao, Z Sun, C Yang… - Scientific Reports, 2024 - nature.com
This study investigates how dynamic fluctuations in matrix stiffness affect the behavior of
cardiac fibroblasts (CFs) within a three-dimensional (3D) hydrogel environment. Using …

Advances in the design, generation, and application of tissue-engineered myocardial equivalents

G Bernava, L Iop - Frontiers in Bioengineering and Biotechnology, 2023 - frontiersin.org
Due to the limited regenerative ability of cardiomyocytes, the disabling irreversible condition
of myocardial failure can only be treated with conservative and temporary therapeutic …