Dysregulated cell division, which leads to aberrant cell proliferation, is one of the key
hallmarks of cancer. Therefore, therapeutic targets that block cell division would be effective …

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially
unchanged for more than 30 years. Osteosarcoma is characterized by widespread and …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Deregulation of the cell cycle machinery, which has been linked to dysregulation of cyclin-
dependent kinases (CDKs), is a defining characteristic of cancer, eventually promoting …

Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …

Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been
approved or have undergone clinical trials and their therapeutic application in multiple …

The undruggable nature of oncogenic Myc transcription factors poses a therapeutic
challenge in neuroblastoma, a pediatric cancer in which MYCN amplification is strongly …

Neuroblastoma is a rare solid tumour of infancy and early childhood with a disproportionate
contribution to paediatric cancer mortality and morbidity. Combination chemotherapy …

An uncontrolled cell cycle is an obvious marker of tumor cells. The G1‑S phase is an
important restriction point in the normal cell cycle, but in cancer cells the restriction function …