Plasmodium vivax is the most widespread human malaria, putting 2.5 billion people at risk of
infection. Its unique biological and epidemiological characteristics pose challenges to …

Organisms can often adapt surprisingly quickly to evolutionary challenges, such as the
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …

Background Primaquine is a key drug for malaria elimination. In addition to being the only
drug active against the dormant relapsing forms of Plasmodium vivax, primaquine is the sole …

Favism and Glucose-6-Phosphate Dehydrogenase Deficiency When persons with G6PD
deficiency eat fava beans, acute hemolytic anemia may develop. It is caused by the …

What is the nature of the genetic changes underlying phenotypic evolution? We have
catalogued 1008 alleles described in the literature that cause phenotypic differences among …

Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

G6PD was discovered and biochemically characterized in 1932 by Otto Warburg and Walter
Christian 1 in yeast and in red cells as an enzyme with a redox function. It was one of the first …

Tuberculosis (TB), usually caused by Mycobacterium tuberculosis bacteria, is the first cause
of death from an infectious disease at the worldwide scale, yet the mode and tempo of TB …

Many human genetic associations with resistance to malaria have been reported, but few
have been reliably replicated. We collected data on 11,890 cases of severe malaria due to …

The high mortality and widespread impact of malaria have resulted in this disease being the
strongest evolutionary selective force in recent human history, and genes that confer …