The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

The alternative pathway is a continuously active surveillance arm of the complement system,
and it can also enhance complement activation initiated by the classical and the lectin …

Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH …

Genome-wide association studies (GWAS) have identified numerous genetic variants in the
human genome associated with diseases and traits. Nevertheless, for most loci the …

The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory
role of complement factor H (FH) in the alternative pathway of the complement system …

Genetic variants within complement factor H (CFH), a major alternative complement pathway
regulator, are associated with the development of age-related macular degeneration (AMD) …

The use of biomaterials in modern medicine has enabled advanced drug delivery strategies
and led to reduced morbidity and mortality in a variety of interventions such as …

After years of disappointing clinical results, the tide has finally changed and complement
targeted-therapies have become a validated and accepted treatment option for several …

Neisseria meningitidis is a leading cause of bacterial septicaemia and meningitis worldwide.
Meningococcal disease is rare but can be life threatening with a tendency to affect children …

Neisseria meningitidis protects itself from complement-mediated killing by binding
complement factor H (FH). Previous studies associated susceptibility to meningococcal …