Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple
organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are …

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding
cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator …

Despite changes in guideline-based management of moderate/severe traumatic brain injury
(TBI) over the preceding decades, little impact on mortality and morbidity have been seen …

Cannabidiol is a natural herbal medicine known to protect the brain from traumatic brain
injury (TBI). Here, a TBI rat model was established, with cannabidiol administered …

Cerebral edema and contusion expansion are major determinants of morbidity and mortality
after TBI. Current treatment options are reactive, suboptimal and associated with significant …

Current approaches have failed to yield success in the translation of neuroprotective
therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous …

Introduction Cerebral edema is a key contributor to death and disability in several forms of
brain injury. Current treatment options are limited, reactive, and associated with significant …

In severe traumatic brain injury (TBI), contusions often are worsened by contusion
expansion or hemorrhagic progression of contusion (HPC), which may double the original …

Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT)
consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury …