Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …

Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …

Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

Many lines of evidence suggest that mitochondria have a central role in ageing-related
neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature …

Several important advances have been made in our understanding of the pathways that
lead to cell dysfunction and death in Parkinson's disease and Huntington's disease. These …