Abstract The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …

Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic
integrity by degrading aged or malfunctioning organelles and damaged or misfolded …

Cannabidiol (CBD), a major nonpsychoactive constituent of cannabis, is considered an
antineoplastic agent on the basis of its in vitro and in vivo activity against tumor cells …

Autophagy is a type of cellular catabolic degradation response to nutrient starvation or
metabolic stress. The main function of autophagy is to maintain intracellular metabolic …

Autophagy, the major lysosomal pathway for recycling intracellular components including
whole organelles, is emerging as a key process modulating tumorigenesis, tumor–stroma …

Multiple oncogenes (in particular phosphatidylinositol 3-kinase, PI3K; activated Akt1;
antiapoptotic proteins from the Bcl-2 family) inhibit autophagy. Similarly, several tumor …

Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …

Autophagy constitutes one of the major responses to stress in eukaryotic cells, and is
regulated by a complex network of signaling cascades. Not surprisingly, autophagy is …

Epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have been
widely used in patients with non-small-cell lung cancer. Unfortunately, the efficacy of EGFR …

Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …