Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Impairments in certain cognitive functions, such as working memory, are core features of
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …

Schizophrenia is a highly debilitating mental disorder that affects∼ 1% of the general
population, yet it continues to be poorly understood. Recent studies have identified …

Synchronization of neuronal activity in the neocortex may underlie the coordination of neural
representations and thus is critical for optimal cognitive function. Because cognitive deficits …

Parvalbumin interneurons are fast-spiking GABAergic neurons that provide inhibitory control
of cortical and subcortical circuits and are thought to be a key locus of the pathophysiology …

Post-mortem morphometric studies report reductions in the average density and size of
cortical neurons in the dorsolateral prefrontal cortex (dlPFC) and orbitofrontal cortex (ORB) …

Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the
patients′ capacity for daily functioning. Whereas our understanding of its pathophysiology …

The core features of schizophrenia include deficits in cognitive processes mediated by the
circuitry of the dorsolateral prefrontal cortex (DLPFC). These deficits are associated with a …

Identifying the molecular alterations that underlie the pathophysiology of critical clinical
features of schizophrenia is an essential step in the rational development of new therapeutic …