The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
Research criteria for the behavioral variant of Alzheimer disease: a systematic review and meta-analysis
R Ossenkoppele, EH Singleton, C Groot… - JAMA …, 2022 - jamanetwork.com
Importance The behavioral variant of Alzheimer disease (bvAD) is characterized by early
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …
Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading
Amyloid-beta and tau are key molecules in the pathogenesis of Alzheimer's disease, but it
remains unclear how these proteins interact to promote disease. Here, by combining cross …
remains unclear how these proteins interact to promote disease. Here, by combining cross …
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
JW Vogel, Y Iturria-Medina, OT Strandberg… - Nature …, 2020 - nature.com
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease
In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity …
Preclinical evidence suggests that tau spreads across connected neurons in an activity …
Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease
N Franzmeier, A Dewenter, L Frontzkowski… - Science …, 2020 - science.org
In Alzheimer's disease (AD), the Braak staging scheme suggests a stereotypical tau
spreading pattern that does, however, not capture interindividual variability in tau deposition …
spreading pattern that does, however, not capture interindividual variability in tau deposition …
Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes
A key hallmark of Alzheimer's disease (AD) pathology is the intracellular accumulation of tau
protein in the form of neurofibrillary tangles across large-scale networks of the human brain …
protein in the form of neurofibrillary tangles across large-scale networks of the human brain …
Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease
Posterior cortical hypometabolism measured with 18F-fluorodeoxyglucose (FDG)-PET is a
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
Network models to enhance the translational impact of cross-species studies
Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …
understanding specific aspects of the human condition. However, the translation of findings …
Medial temporal lobe networks in Alzheimer's disease: structural and molecular vulnerabilities
The medial temporal lobe (MTL) is connected to the rest of the brain through two main
networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the …
networks: the anterior-temporal (AT) and the posterior-medial (PM) systems. Given the …