Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Abstract FBXW7 (F-Box and WD Repeat Domain Containing 7)(also referred to as FBW7 or
hCDC4) is a component of the Skp1-Cdc53/Cullin-F-box-protein complex (SCF/β-TrCP). As …

Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its
high metastatic and recurrent nature. Although various therapeutic strategies are currently in …

Purpose: The genetic intratumoral heterogeneity observed in human osteosarcomas poses
challenges for drug development and the study of cell fate, plasticity, and differentiation …

Simple Summary YAP and TAZ are both transcriptional co-activators in the Hippo pathway.
New evidence reveals that they have unique and overlapping functions during tumor …

Primary bone cancers (PBC) belong to the family of mesenchymal tumors classified based
on their cellular origin, extracellular matrix, genetic regulation, and epigenetic modification …

The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic
regulators of adult tissue homeostasis maintaining organ integrity and self-renewal …

Cellular apoptosis is a central mechanism leveraged by chemotherapy to treat human
cancers. 5‐Methylcytosine (m5C) modifications installed on both DNA and mRNA are …

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and
plays a key role in tumor progression. However, the precise molecular mechanisms …

In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At
present, management options to prevent metastasis are limited and non-curative. In this …