Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to
successfully colonize their hosts. In recent years, there has been increased recognition that …

The prevalence of gastric cancer is associated with several factors including geographical
location, diet, and genetic background of the host. However, it is evident that infection with …

Helicobacter pylori is the strongest known risk factor for gastric adenocarcinoma, and strains
that possess the cag secretion system, which translocates the bacterial effector CagA into …

OBJECTIVES: Helicobacter pylori is an identified carcinogen for gastric cancer, however, the
underlying mechanisms remain to be defined. In this review, we sought to elucidate the role …

The vacuolating cytotoxin VacA produced by Helicobacter pylori causes massive cellular
vacuolation in vitro,, and gastric tissue damage in vivo, leading to gastric ulcers, when …

Helicobacter pylori infection, which is always associated with gastritis, can progress to
ulceration or malignancy. The diversity in clinical outcomes is partly attributed to the …

With the momentous discovery in the 1980′ s that a bacterium, Helicobacter pylori, can
cause peptic ulcer disease and gastric cancer, antibiotic therapies and prophylactic …

Helicobacter pylori cag+ strains enhance gastric epithelial cell proliferation and attenuate
apoptosis in vivo, which may partially explain the increased risk of gastric cancer associated …

Helicobacter pylori has been suggested to play a role in the development of gastric
carcinoma in humans. Also, mounting evidence indicates that cyclooxygenase-2 …

Background & Aims: Human colonization with Helicobacter pylori increases the risk for distal
gastric adenocarcinoma, possibly by altering gastric epithelial cell cycle events and/or …