Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Recent studies have revealed multiple dynamic complexes that are precursors to eukaryotic
ribosomes. EM visualization of nascent rRNA transcripts provides in vivo temporal and …

The Saccharomyces cereivisiae gene deletion project revealed that approximately 20% of
yeast genes are required for viability. The analysis of essential genes traditionally relies on …

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations
in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of …

The small subunit (SSU) processome is a 2.2‐MDa ribonucleoprotein complex involved in
the processing, assembly, and maturation of the SSU of eukaryotic ribosomes. The identities …

Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes
and is known to require> 170 genes for the assembly, modification, and trafficking of …

The 90S preribosomal particle is required for the production of the 18S rRNA from a pre-
rRNA precursor. Despite the identification of the protein components of this particle, its …

The YgjD/Kae1 family (COG0533) has been on the top‐10 list of universally conserved
proteins of unknown function for over 5 years. It has been linked to DNA maintenance in …