The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Background Zero-dimensional (lumped parameter) and one dimensional models, based on
simplified representations of the components of the cardiovascular system, can contribute …

The cardiac muscle and the coronary vasculature are in close proximity to each other, and a
two-way interaction, called cross-talk, exists. Here we focus on the mechanical aspects of …

Albuminuria is closely associated with stroke and cardiovascular diseases (CVDs) as well
as the salt sensitivity of blood pressure (BP). Although albuminuria may reflect generalized …

In deriving clinically used hemodynamic indices such as fractional flow reserve and
coronary flow velocity reserve, simplified models of the coronary circulation are used. In …

Documentation of inducible myocardial ischaemia, related to the coronary stenosis of
interest, is of increasing importance in lesion selection for percutaneous coronary …

The autoregulation of blood flow, the maintenance of almost constant blood flow in the face
of variations in arterial pressure, is characteristic of many tissue types. Here, contributions to …

Myocardial ischemia is transmurally heterogeneous where the subendocardium is at higher
risk. Stenosis induces reduced perfusion pressure, blood flow redistribution away from the …

Myogenic response, flow-dependent dilation, and direct metabolic control are important
mechanisms controlling coronary flow. A model was developed to study how these control …

Blood flow regulation by small arteries and arterioles includes adaptation of both vascular
tone and structure. It is becoming clear that tone and remodeling of resistance vessels are …