Shigella spp. that are resistant to almost all antimicrobial classes are increasing in
prevalence and becoming globally dominant. The situation is critical and highlights a trend …

Antimicrobial resistance (AMR) is an increasingly concerning phenomenon that requires
urgent attention because it poses a threat to human and animal health. Bacteria undergo …

The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows
potent bactericidal activity against Mycobacterium abscessus in vitro. Here, we report that …

Shigella is an important human-adapted pathogen which contributes to a large global
burden of diarrhoeal disease. Together with the increasing threat of antimicrobial resistance …

Background Global pediatric healthcare reveals significant morbidity and mortality rates
linked to respiratory, cardiac, and gastrointestinal disorders in children and newborns …

With increasing antibiotic resistance in gram-negative bacteria, including those causing
Shigellosis, evidence of safety and pharmacokinetics data on new oral antibiotics is crucial …

Multiple drug-resistant (MDR) Shigella isolates have been reported worldwide. Between
May 2017 and September 2018, 55 Shigella flexneri 2a isolates were collected from 3322 …

Shigella flexneri is a facultative intracellular pathogen that causes shigellosis, a human
diarrheal disease characterized by the destruction of the colonic epithelium. Novel …

The ability to control bacterial infection transformed the practice of medicine. Of the first
antibacterial compounds isolated from Nature nearly a century ago—the gramicidins, the …

Abstract Background and Objective Tebipenem pivoxil (TP) is a carbapenem and is applied
against pneumonia, otitis media, and sinusitis. This study compared the pharmacokinetics …