Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

Numerous electrophilic metabolites are formed during cellular activity, particularly under
conditions of oxidative, inflammatory and metabolic stress. Among them are lipid oxidation …

Glioma is the most prevalent brain tumor, presenting with limited treatment options, while
patients with malignant glioma and glioblastoma (GBM) have poor prognoses. The physical …

Enzyme-assisted posttranslational modifications (PTMs) constitute a major means of
signaling across different cellular compartments. However, how nonenzymatic PTMs …

Humans have widespread exposure to both oxidants, and soft electrophilic compounds such
as alpha, beta-unsaturated aldehydes and quinones. Electrophilic motifs are commonly …

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux
attributable to on-target, vis-à-vis off-target, modifications. By combining bolus dosing …

Abstract This Protocol Extension describes the adaptation of an existing Protocol detailing
the use of targetable reactive electrophiles and oxidants, an on-demand redox targeting …

First established in the seventies, proteomics, chemoproteomics, and most recently,
spatial/proximity-proteomics technologies have empowered researchers with new …

Our bodies produce a host of electrophilic species that can label specific endogenous
proteins in cells. The signaling roles of these molecules are under active debate. However …

Intracerebral hemorrhage (ICH) is a hemorrhagic stroke with a high mortality and disability
rate. Neurological impairment after ICH is closely associated with neuronal axon damage …