Plasmodium falciparum remains the deadliest parasite species in the world, responsible for
229 million cases of human malaria in 2019. The ability of the P. falciparum parasite to …

Due to the unique selective pressures and extreme changes faced by the human malaria
parasite Plasmodium falciparum throughout its life cycle, the parasite has evolved distinct …

We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a
druggable target, using genetic and chemical validation. In vitro evolution of resistance with …

The epigenome of the malaria parasite, Plasmodium falciparum, is associated with
regulation of various essential processes in the parasite including control of proliferation …

Metabolic reprogramme was a key characteristic of malignant tumors. Increased evidences
indicated that besides Warburg effect (abnormal glucose metabolism), abnormal lipid …

The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond
the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To …

Histone posttranslational modifications (PTMs) frequently co-occur on the same chromatin
domains or even in the same molecule. It is now established that these" histone codes" are …

Adult oligodendrocyte progenitors (aOPCs) generate myelinating oligodendrocytes like
neonatal progenitors (nOPCs), and they also display unique functional features. Here, using …

Proteome-wide lysine acetylation has been documented in apicomplexan parasite
Toxoplasma gondii and Plasmodium falciparum. Here, we conducted the first lysine …

The host–pathogen interaction is a multifactorial process subject to a co-evolutionary arms
race consisting of rapid changes in both host and pathogen, controlled at the genetic and …