Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Areas of hypoxic tumour tissue are known to be resistant to treatment and are associated
with a poor clinical prognosis. There are several reasons why this might be, including the …

Activation of telomerase is a critical step in the development of about 85% of human
cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are …

Background Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is a
common dietary component that has histone deacetylase inhibition activity and exciting …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

The papillomaviruses are small DNA viruses that encode approximately eight genes, and
require the host cell DNA replication machinery for their viral DNA replication. Thus …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Telomerase activity plays an essential role in cell survival, by lengthening telomeres and
promoting cell growth and longevity. It is now possible to quantify the low levels of …

Hypoxia in solid tumors is associated with the development of chemoresistance. Although
many studies have focused on the effect of hypoxia on drug-induced apoptosis, the effect of …