BACKGROUND: Exercise-based cardiac rehabilitation (CR) remains an underused tool for
secondary prevention post–myocardial infarction (MI). In part, this arises from uncertainty …

We hypothesized that high-intensity aerobic interval training results in a greater beneficial
adaptation of the heart compared with that observed after low-to-moderate exercise …

Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Abstract Cardiovascular (CV) disease (CVD) remains the leading cause of major morbidity
and CVD-and all-cause mortality in most of the world. It is now clear that regular physical …

Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Background: An in-depth understanding of the fundamental principles that regulate thyroid
hormone homeostasis is critical for the development of new diagnostic and treatment …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

In human cardiomyopathy, anatomical abnormalities such as hypertrophy and fibrosis
contribute to the risk of ventricular arrhythmias and sudden death. Here we have shown that …

The association between reduced myofilament force-generating capacity (Fmax) and heart
failure (HF) is clear, however the underlying molecular mechanisms are poorly understood …