Mammalian skin research represents the convergence of three complementary disciplines:
cell biology, mouse genetics, and dermatology. The skin provides a paradigm for current …

The establishment and maintenance of epithelial cell-cell junctions is crucially important to
regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Desmosomes are cell-cell adhesive organelles with a well-known role in forming strong
intercellular adhesion during embryogenesis and in adult tissues subject to mechanical …

Desmosomes have long been appreciated as intercellular junctions that are vital for
maintaining the structural integrity of stratified epithelia. More recent clinical investigations of …

The regulation of adhesion and growth is important for epithelial function and dysfunction. β-
catenin (armadillo in Drosophila) is the prototype of a multifunctional molecule that regulates …

The intestinal mucosa is lined by a single layer of epithelial cells that forms a tight barrier,
separating luminal antigens and microbes from underlying tissue compartments. Mucosal …

Background Lung cancer is one of the most aggressive tumors with high incidence and
mortality, which could be classified into lung squamous cell carcinoma (LUSC) and lung …

Despite its central position in oncogenic intracellular signaling networks, the role of
mTORC1 in epithelial development has not been studied extensively in vivo. Here, we have …

Purpose Capillary leak syndrome (CLS) is an intermediary phase between severe acute
pancreatitis (SAP) and multiple organ failure. As a result, CLS is of clinical importance for …