Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

Abstract The Chronic Renal Insufficiency Cohort (CRIC) Study is an ongoing, multicenter,
longitudinal study of nearly 5500 adults with CKD in the United States. Over the past 10 …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …

Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …

An ability to separate natural ageing processes from processes specific to morbidities is
required to understand the heterogeneity of age-related organ dysfunction. Mechanistic …

Background Rapid progression of CKD is associated with poor clinical outcomes. Despite
extensive study of the genetics of cross-sectional eGFR, only a few loci associated with …

The identification of genetic factors associated with kidney disease has the potential to
provide critical insights into disease mechanisms. Genome-wide association studies have …

Results Among 2943 participants, mean age was 58 years, 45% were women, and 48% self-
identified as Black. There were 1077 patients who experienced CKD progression over a …