4-Thiazolidinone-bearing hybrid molecules in anticancer drug design
Oncological diseases have currently reached an epidemic scale, especially in industrialized
countries. Such a situation has prompted complex studies in medicinal chemistry focused on …
countries. Such a situation has prompted complex studies in medicinal chemistry focused on …
Phenylpyrazolone-1, 2, 3-triazole hybrids as potent antiviral agents with promising SARS-CoV-2 main protease inhibition potential
COVID-19 infection is now considered one of the leading causes of human death. As an
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen …
Two neoteric pyrazole compounds as potential anti-cancer agents: synthesis, electronic structure, physico-chemical properties and docking analysis
Abstract The pyrazole derivatives,(E)-4-(2-(3-chlorophenyl) hydrazono)-5-methyl-2, 4-
dihydro-3H-pyrazol-3-one (CPHMP) and 4-(2-(2, 4, 5-trichlorophenyl) hydrazinyl)-2, 4 …
dihydro-3H-pyrazol-3-one (CPHMP) and 4-(2-(2, 4, 5-trichlorophenyl) hydrazinyl)-2, 4 …
Molecular hybrids based on Pyrazole and 4-Thiazolidinone cores: Synthesis, characterization, and anticancer studies
M Mushtaque, MMA Rizvi - Journal of Molecular Structure, 2023 - Elsevier
A series of hybrid compounds (11a–d) bearing pyrazole (6a–d) and 4-thiazolidinone (10)
cores were synthesized and characterized. The molecular structure of the compounds was …
cores were synthesized and characterized. The molecular structure of the compounds was …
Synthesis, characterization, and pharmacological studies of ferrocene-1H-1, 2, 3-triazole hybrids
A series of ferrocene-1H-1, 2, 3-triazole hybrids namely 1-(4-nitrophenyl)-4-ferrocenyl-1H-1,
2, 3-triazole (1), 1-(4, 4′-dinitro-2-biphenyl)-4-ferrocenyl-1H-1, 2, 3-triazole (2), 1-(3-chloro …
2, 3-triazole (1), 1-(4, 4′-dinitro-2-biphenyl)-4-ferrocenyl-1H-1, 2, 3-triazole (2), 1-(3-chloro …
Synthesis, characterization, anticancer and in silico studies of a pyrazole-tethered thiazolidine-2,4-dione derivative
MM Alshammari, R Soury, KM Alenezi… - Journal of …, 2022 - Taylor & Francis
A new pyrazole-tethered thiazolidine-2, 4-dione derivative (8) has been synthesized by the
Knoevenagel condensation of 3-(4-nitrophenyl)-1-phenyl-1 H-pyrazole-4-carbaldehyde (4) …
Knoevenagel condensation of 3-(4-nitrophenyl)-1-phenyl-1 H-pyrazole-4-carbaldehyde (4) …
A new series of cytotoxic pyrazoline derivatives as potential anticancer agents that induce cell cycle arrest and apoptosis
H Wang, J Zheng, W Xu, C Chen, D Wei, W Ni, Y Pan - Molecules, 2017 - mdpi.com
A new series of pyrazoline derivatives 1b–12b was designed, synthesized and evaluated for
antiproliferative activity against three cancer cell lines (HepG-2, Hela and A549) …
antiproliferative activity against three cancer cell lines (HepG-2, Hela and A549) …
Designing of phenol-based β−carbonic anhydrase1 inhibitors through QSAR, molecular docking, and MD simulation approach
Tuberculosis (Tb) is an airborne infectious disease caused by Mycobacterium tuberculosis.
Beta-carbonic anhydrase 1 (β-CA1) has emerged as one of the potential targets for new …
Beta-carbonic anhydrase 1 (β-CA1) has emerged as one of the potential targets for new …
Development of a DABCO-Succinic Acid Based Catalytic System for the Aza-Michael Addition and Aza-Michael/Knoevenagel Tandem Reaction of Thiazolidine-2, 4 …
A DABCO catalyzed aza-Michael addition of thiazolidine-2, 4-dione to a variety of electron
deficient alkenes has been developed. Additionally, a DABCO/succinic acid salt system has …
deficient alkenes has been developed. Additionally, a DABCO/succinic acid salt system has …
Designing of new tetrahydro-β-carboline-based ABCG2 inhibitors using 3D-QSAR, molecular docking, and DFT tools
Human ATP-binding cassette superfamily G member 2 (ABCG2) protein is a member of the
ABC transporter family, which is responsible for multidrug resistance (MDR) in cancerous …
ABC transporter family, which is responsible for multidrug resistance (MDR) in cancerous …