The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of
function mutations in the genes encoding dystrophin, or the associated proteins, triggers …

Associations between cells and the basement membrane are critical for a variety of
biological events including cell proliferation, cell migration, cell differentiation and the …

Glycosylation is an essential post-translational modification that underlies many biological
processes and diseases. α-dystroglycan (α-DG) is a receptor for matrix and synaptic proteins …

Phosphorylated O-mannosyl trisaccharide [N-acetylgalactosamine–β3-N-acetylglucosamine–
β4-(phosphate-6-) mannose] is required for dystroglycan to bind laminin-G domain …

The metazoan O-mannose (O-Man) glycoproteome is largely unknown. It has been shown
that up to 30% of brain O-glycans are of the O-Man type, but essentially only alpha …

The post-translational glycosylation of select proteins by O-linked mannose (O-mannose or
O-man) is a conserved modification from yeast to humans and has been shown to be …

Cobblestone lissencephaly is a peculiar brain malformation with characteristic radiological
anomalies. It is defined as cortical dysplasia that results when neuroglial overmigration into …

Lassa virus is estimated to cause thousands of human deaths per year, primarily due to
spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody …

The movement of proteins between cellular compartments requires the orchestrated actions
of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors …

Background Global analyses of proteins and their modifications by mass spectrometry are
essential tools in cell biology and biomedical research. Analyses of glycoproteins represent …