The role of the local microbial ecosystem in respiratory health and disease

WAA de Steenhuijsen Piters… - … Transactions of the …, 2015 - royalsocietypublishing.org
Respiratory tract infections are a major global health concern, accounting for high morbidity
and mortality, especially in young children and elderly individuals. Traditionally, highly …

Peptide pheromone signaling in Streptococcus and Enterococcus

LC Cook, MJ Federle - FEMS microbiology reviews, 2014 - academic.oup.com
Intercellular chemical signaling in bacteria, commonly referred to as quorum sensing (QS),
relies on the production and detection of compounds known as pheromones to elicit …

Two group A streptococcal peptide pheromones act through opposing Rgg regulators to control biofilm development

JC Chang, B LaSarre, JC Jimenez, C Aggarwal… - PLoS …, 2011 - journals.plos.org
Streptococcus pyogenes (Group A Streptococcus, GAS) is an important human commensal
that occasionally causes localized infections and less frequently causes severe invasive …

Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections

B Gray, P Hall, H Gresham - Sensors, 2013 - mdpi.com
Invasive infection by the Gram-positive pathogen Staphylococcus aureus is controlled by a
four gene operon, agr that encodes a quorum sensing system for the regulation of virulence …

Graded decisions in the human brain

T Xie, M Adamek, H Cho, MA Adamo… - Nature …, 2024 - nature.com
Decision-makers objectively commit to a definitive choice, yet at the subjective level, human
decisions appear to be associated with a degree of uncertainty. Whether decisions are …

Alternative approaches to treat bacterial infections: targeting quorum-sensing

P Piewngam, J Chiou, P Chatterjee… - Expert review of anti …, 2020 - Taylor & Francis
Introduction The emergence of multi-and pan-drug-resistant bacteria represents a global
crisis that calls for the development of alternative anti-infective strategies. These comprise …

Quorum sensing in group A Streptococcus

JC Jimenez, MJ Federle - Frontiers in cellular and infection …, 2014 - frontiersin.org
Quorum sensing (QS) is a widespread phenomenon in the microbial world that has
important implications in the coordination of population-wide responses in several bacterial …

ABC transporters of antimicrobial peptides in F irmicutes bacteria–phylogeny, function and regulation

S Gebhard - Molecular microbiology, 2012 - Wiley Online Library
Antimicrobial peptides (AMPs) are a group of antibiotics that mainly target the cell wall of G
ram‐positive bacteria. Resistance is achieved by a variety of mechanisms including target …

Molecular epidemiology and genomics of group A Streptococcus

DE Bessen, WM McShan, SV Nguyen, A Shetty… - Infection, Genetics and …, 2015 - Elsevier
Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a
very high prevalence worldwide. This review highlights the genetic organization of the …

[HTML][HTML] An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation

M Baruch, I Belotserkovsky, BB Hertzog, M Ravins… - Cell, 2014 - cell.com
Successful infection depends on the ability of the pathogen to gain nutrients from the host.
The extracellular pathogenic bacterium group A Streptococcus (GAS) causes a vast array of …