The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

K Rodolaki, V Pergialiotis, N Iakovidou… - Frontiers in …, 2023 - frontiersin.org
Maternal health during gestational period is undoubtedly critical in shaping optimal fetal
development and future health of the offspring. Gestational diabetes mellitus is a metabolic …

Animal models of gestational diabetes: characteristics and consequences to the brain and behavior of the offspring

RAL De Sousa - Metabolic Brain Disease, 2021 - Springer
Gestational diabetes (GD) is the glucose intolerance that occurs during pregnancy. Mothers
who develop diabetes during gestation are at increased risk of developing type 2 diabetes …

Effects of endurance exercise and Urtica dioica on the functional, histological and molecular aspects of the hippocampus in STZ-Induced diabetic rats

M Keshvari, M Rahmati, R Mirnasouri… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Many body systems and organs, including the
hippocampus, are affected by diabetes, and undergo changes that may increase the risk of …

Gestational diabetes exacerbates maternal immune activation effects in the developing brain

KM Money, TL Barke, A Serezani, M Gannon… - Molecular …, 2018 - nature.com
Maternal inflammation and diabetes increase the risk for psychiatric disorders in offspring.
We hypothesized that these co-occurring risk factors may potentiate each other. To test this …

Associations among prenatal exposure to gestational diabetes mellitus, brain structure, and child adiposity markers

S Luo, E Hsu, KE Lawrence, S Adise, TA Pickering… - …, 2023 - Wiley Online Library
Objective The aim of this study was to investigate the mediating role of child brain structure
in the relationship between prenatal gestational diabetes mellitus (GDM) exposure and child …

Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children

S Zhao, L Semeia, R Veit, S Luo, BC Angelo… - International Journal of …, 2024 - nature.com
Objectives Intrauterine exposure to gestational diabetes mellitus (GDM) increases the risk of
obesity in the offspring, but little is known about the underlying neural mechanisms. The …

Selective morphological and volumetric alterations in the hippocampus of children exposed in utero to gestational diabetes mellitus

KM Lynch, JM Alves, T Chow, KA Clark… - Human brain …, 2021 - Wiley Online Library
Prior epidemiological studies have found that in utero exposure to gestational diabetes
mellitus (GDM) is associated with increased risk for neurodevelopmental disorders …

Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: implication of cilostazol for diabetes mellitus-induced …

KJ Kwon, EJ Lee, MK Kim, SY Kim, JN Kim… - Neurobiology of …, 2015 - Elsevier
Many patients with diabetes are at increased risk of cognitive dysfunction and dementia.
Diabetes mellitus is a vascular risk factor that may increase the risk of dementia through its …

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy, and ventricular enlargement with intracerebroventricular streptozotocin …

A Roy, S Sharma, TC Nag, J Katyal, YK Gupta… - Neurotoxicity …, 2022 - Springer
Insulin-resistant brain state is proposed to be the early sign of Alzheimer's disease (AD),
which can be studied in the intracerebroventricular streptozotocin (ICV-STZ) rodent model …

Gestational diabetes triggers oxidative stress in hippocampus and cerebral cortex and cognitive behavior modifications in rat offspring: Age-and sex-dependent effects

M Huerta-Cervantes, DJ Peña-Montes… - Nutrients, 2020 - mdpi.com
Gestational diabetes (GD) has been linked with an increased risk of developing metabolic
disorders and behavioral abnormalities in the offspring. Oxidative stress is strongly …