Nucleoside analogues for the treatment of coronavirus infections
AJ Pruijssers, MR Denison - Current opinion in virology, 2019 - Elsevier
Highlights•Coronaviruses (CoV) represent current and future risk for pandemic zoonotic
infections.•Nucleoside analogues are highly active across multiple virus families.•CoVs …
infections.•Nucleoside analogues are highly active across multiple virus families.•CoVs …
[HTML][HTML] Cryo-electron microscopy and X-ray crystallography: complementary approaches to structural biology and drug discovery
C Vénien-Bryan, Z Li, L Vuillard… - … Section F: Structural …, 2017 - scripts.iucr.org
The invention of the electron microscope has greatly enhanced the view scientists have of
small structural details. Since its implementation, this technology has undergone …
small structural details. Since its implementation, this technology has undergone …
High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment
The present-day world is severely suffering from the recently emerged SARS-CoV-2. The
lack of prescribed drugs for the deadly virus has stressed the likely need to identify novel …
lack of prescribed drugs for the deadly virus has stressed the likely need to identify novel …
TREX1 as a novel immunotherapeutic target
WO Hemphill, SR Simpson, M Liu… - Frontiers in …, 2021 - frontiersin.org
Mutations in the TREX1 3'→ 5'exonuclease are associated with a spectrum of autoimmune
disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS …
disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS …
In silico evidence of beauvericin antiviral activity against SARS-CoV-2
Background Scientists are still battling severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the virus responsible for the coronavirus 2019 (COVID-19) pandemic so …
(SARS-CoV-2), the virus responsible for the coronavirus 2019 (COVID-19) pandemic so …
Analogs of the catechol derivative dynasore inhibit HIV-1 ribonuclease H, SARS-CoV-2 nsp14 exoribonuclease, and virus replication
Viral replication often depends on RNA maturation and degradation processes catalyzed by
viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we …
viral ribonucleases, which are therefore candidate targets for antiviral drugs. Here, we …
[HTML][HTML] The cyclophilin-dependent calcineurin inhibitor voclosporin inhibits SARS-CoV-2 replication in cell culture
NS Ogando, E Metscher, DJAR Moes… - Transplant …, 2022 - frontierspartnerships.org
Kidney transplant recipients (KTRs) are at increased risk for a more severe course of COVID-
19, due to their pre-existing comorbidity and immunosuppression. Consensus protocols …
19, due to their pre-existing comorbidity and immunosuppression. Consensus protocols …
The role of conserved residues in the DEDDh motif: the proton-transfer mechanism of HIV-1 RNase H
RNase H is a prototypical example for two-metal-ion catalysis in enzymes. An RNase H
activity cleaving the ribonucleic acid (RNA) backbone of a DNA/RNA hybrid is present not …
activity cleaving the ribonucleic acid (RNA) backbone of a DNA/RNA hybrid is present not …
A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein
The arenavirus nucleoprotein (NP) plays an important role in the virus' ability to block
interferon (IFN) production, and its exonuclease function appears to contribute to this activity …
interferon (IFN) production, and its exonuclease function appears to contribute to this activity …
Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase
R Nandi, D Bhowmik, R Srivastava… - Journal of …, 2022 - Taylor & Francis
The rise in the incidence of COVID-19 as a result of SARS-CoV-2 infection has threatened
public health globally. Till now, there have been no proper prophylactics available to fight …
public health globally. Till now, there have been no proper prophylactics available to fight …