Blood is the pipeline of the immune system. Assessing changes in transcript abundance in
blood on a genome-wide scale affords a comprehensive view of the status of the immune …

Heterogeneity in the underlying mechanisms of disease processes and inter-patient
variability in drug responses are major challenges in drug development. To address these …

A major challenge for kidney transplantation is balancing the need for immunosuppression
to prevent rejection, while minimizing drug‐induced toxicities. We used DNA microarrays …

At present, the diagnosis of renal allograft rejection requires a renal biopsy. Clinical
management of renal transplant patients would be improved by the development of non …

Histopathologic diagnoses in transplantation can be improved with molecular testing.
Preferably, molecular diagnostics should fit into standard‐of‐care workflows for transplant …

The degree of progressive chronic histological damage is associated with long-term renal
allograft survival. In order to identify promising molecular targets for timely intervention, we …

We assessed the molecular phenotype of 107 6-week protocol biopsies from human renal
allografts, using Affymetrix microarrays. Transcript changes were summarized as …

Background and objectives: The outcome of renal transplantation after an episode of acute
rejection is difficult to predict, even with an allograft biopsy. We examined whether urinary …

Chronic antibody‐mediated rejection (CAMR) represents the main cause of kidney graft
loss. To uncover the molecular mechanisms underlying this condition, we characterized the …

The clinical success of new treatment strategies aiming on inducing permanent graft
acceptance will rely on the ability to determine whether specific unresponsiveness to donor …