Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

The skin epidermis is constantly renewed throughout life,. Disruption of the balance between
renewal and differentiation can lead to uncontrolled growth and tumour initiation. However …

Rationale: Clonal hematopoiesis driven by mutations of DNMT3A (DNA methyltransferase
3a) is associated with increased incidence of cardiovascular disease and poor prognosis of …

Here we delineate the ontogeny of the mammalian endoderm by generating 112,217 single-
cell transcriptomes, which represent all endoderm populations within the mouse embryo …

Interactions between tumour cells and the surrounding microenvironment contribute to
tumour progression, metastasis and recurrence,–. Although mosaic analyses in Drosophila …

The tumour microenvironment plays a critical role in determining tumour fate. Within that
environment, and indeed throughout epithelial tissues, cells experience competition with …

Cell competition—the sensing and elimination of less fit 'loser'cells by neighbouring
'winner'cells—was first described in Drosophila. Although cell competition has been …

An emerging view emphasizes that metabolism is highly regulated in both time and space.
In addition, it is increasingly being recognized that metabolic pathways are tightly connected …

An increasing evidence supports that cell competition, a vital selection and quality control
mechanism in multicellular organisms, is involved in tumorigenesis and development; …