NCX proteins explore the electrochemical gradient of Na+ to mediate Ca 2+-fluxes in
exchange with Na+ either in the Ca 2+-efflux (forward) or Ca 2+-influx (reverse) mode …

Background Due to its unique physical and chemical properties, lead is still used worldwide
in several applications, especially in industry. Both environmental and industrial lead …

Abstract Na+/Ca2+ exchangers (NCX) transport Ca2+ in or out of cells in exchange for Na+.
They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca2+ …

Ca 2+ homeostasis is essential for cell function and survival. As such, the cytosolic Ca 2+
concentration is tightly controlled by a wide number of specialized Ca 2+ handling proteins …

Na+/Ca2+ exchangers (NCXs) are ubiquitous membrane transporters with a key role in
Ca2+ homeostasis and signaling. NCXs mediate the bidirectional translocation of either Na+ …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …

Na+/Ca2+ exchanger (NCX) proteins extrude Ca2+ from the cell to maintain cellular
homeostasis. Since NCX proteins contribute to numerous physiological and …

In analogy with many other proteins, Na+/Ca2+ exchangers (NCX) adapt an inverted twofold
symmetry of repeated structural elements, while exhibiting a functional asymmetry by …

Abstract Cytosolic Ca2+ and Na+ allosterically regulate Na+/Ca2+ exchanger (NCX)
proteins to vary the NCX-mediated Ca2+ entry/exit rates in diverse cell types. To resolve the …