Diagnosis of human immunodeficiency virus infection

BS Parekh, CY Ou, PN Fonjungo… - Clinical microbiology …, 2018 - Am Soc Microbiol
SUMMARY HIV diagnostics have played a central role in the remarkable progress in
identifying, staging, initiating, and monitoring infected individuals on life-saving antiretroviral …

HIV-1 drug resistance genotyping in resource limited settings: current and future perspectives in sequencing technologies

S Manyana, L Gounder, M Pillay, J Manasa, K Naidoo… - Viruses, 2021 - mdpi.com
Affordable, sensitive, and scalable technologies are needed for monitoring antiretroviral
treatment (ART) success with the goal of eradicating HIV-1 infection. This review discusses …

Affordable HIV drug-resistance testing for monitoring of antiretroviral therapy in sub-Saharan Africa

SC Inzaule, P Ondoa, T Peter, PN Mugyenyi… - The Lancet Infectious …, 2016 - thelancet.com
Increased provision of antiretroviral therapy in sub-Saharan Africa has led to a growing
number of patients with therapy failure and acquired drug-resistant HIV, driving the demand …

Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa

LT Matthews, M Jaggernath, Y Kriel, PM Smith… - AIDS, 2024 - journals.lww.com
Objective: We developed the Healthy Families-PrEP intervention to support HIV-prevention
during periconception and pregnancy. We evaluated preexposure prophylaxis (PrEP) use …

HIV-1 drug resistance and third-line therapy outcomes in patients failing second-line therapy in Zimbabwe

C Chimbetete, D Katzenstein, T Shamu… - Open forum …, 2018 - academic.oup.com
Objectives To analyze the patterns and risk factors of HIV drug resistance mutations among
patients failing second-line treatment and to describe early treatment responses to …

[HTML][HTML] HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral therapy in KwaZulu-Natal Province, South Africa

B Chimukangara, RJ Lessells, B Sartorius… - Journal of Global …, 2022 - Elsevier
Objectives In low–middle-income countries, increasing levels of HIV drug resistance
(HIVDR) on second-line protease inhibitor (PI)-based regimens are a cause for concern …

Virological outcomes of second-line protease inhibitor–based treatment for human immunodeficiency virus type 1 in a high-prevalence rural South African setting: a …

D Collier, C Iwuji, A Derache… - Clinical infectious …, 2017 - academic.oup.com
Background. Second-line antiretroviral therapy (ART) based on ritonavir-boosted protease
inhibitors (bPIs) represents the only available option after first-line failure for the majority of …

Moderate-to-high levels of pretreatment HIV drug resistance in KwaZulu-Natal Province, South Africa

B Chimukangara, ABM Kharsany… - AIDS research and …, 2019 - liebertpub.com
There is evidence of increasing levels of pretreatment HIV drug resistance (PDR) in
Southern Africa. We used data from two large population-based HIV surveillance studies to …

Drug resistance and optimizing dolutegravir regimens for adolescents and young adults failing antiretroviral therapy

V Kouamou, J Manasa, D Katzenstein, AM McGregor… - Aids, 2019 - journals.lww.com
Objectives: The integrase strand inhibitor dolutegravir (DTG) combined with tenofovir and
lamivudine (TLD) is a single tablet regimen recommended for 1st, 2nd and 3rd-line public …

[PDF][PDF] The evolving landscape of HIV drug resistance diagnostics for expanding testing in resource-limited settings

SC Inzaule, RL Hamers, R Paredes, C Yang… - AIDS Rev, 2017 - researchgate.net
Global scale-up of antiretroviral treatment has dramatically changed the prospects of
HIV/AIDS disease, rendering life-long chronic care and treatment a reality for millions of HIV …