Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …

SAR11 is a group of small, carbon-oxidizing bacteria that reach a global estimated
population size of 2.4× 1028 cells—approximately 25% of all plankton. They are found …

Coevolution between bacteriophages (phages) and their bacterial hosts occurs through
changes in resistance and counter-resistance mechanisms. To assess phage–host …

The perpetual arms race between bacteria and phage has resulted in the evolution of
efficient resistance systems that protect bacteria from phage infection. Such systems, which …

Several reports proposed that the extraordinary dominance of the SAR11 bacterial clade in
ocean ecosystems could be a consequence of unusual mechanisms of resistance to …

Bacteria have evolved diverse mechanisms to fend off predation by bacteriophages. We
previously identified the Dnd system, which uses DndABCDE to insert sulfur into the DNA …

Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPDQ), one of
the oxidation products of rubber antioxidant 6PPD, has been identified as a novel toxicant to …

Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems, especially type II (Cas9) systems, have been widely used in …

While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA,
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …

The 1952 observation of host-induced non-hereditary variation in bacteriophages by
Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that …