Arsenic: a global environmental challenge

QY Chen, M Costa - Annual Review of Pharmacology and …, 2021 - annualreviews.org
Arsenic is a naturally occurring metalloid and one of the few metals that can be metabolized
inside the human body. The pervasive presence of arsenic in nature and anthropogenic …

Toxicity testing in the 21st century: progress in the past decade and future perspectives

D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

The duality of arsenic metabolism: impact on human health

MA El-Ghiaty, AOS El-Kadi - Annual review of pharmacology …, 2023 - annualreviews.org
Arsenic is a naturally occurring hazardous element that is environmentally ubiquitous in
various chemical forms. Upon exposure, the human body initiates an elimination pathway of …

[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds

I Khairul, QQ Wang, YH Jiang, C Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies …

Arsenic and environmental health: state of the science and future research opportunities

DJ Carlin, MF Naujokas, KD Bradham… - Environmental …, 2016 - ehp.niehs.nih.gov
Background: Exposure to inorganic and organic arsenic compounds is a major public health
problem that affects hundreds of millions of people worldwide. Exposure to arsenic is …

[HTML][HTML] Environmental arsenic exposure: from genetic susceptibility to pathogenesis

BC Minatel, AP Sage, C Anderson, R Hubaux… - Environment …, 2018 - Elsevier
More than 200 million people in 70 countries are exposed to arsenic through drinking water.
Chronic exposure to this metalloid has been associated with the onset of many diseases …

Health effects inflicted by chronic low‐level arsenic contamination in groundwater: A global public health challenge

D Sinha, P Prasad - Journal of Applied Toxicology, 2020 - Wiley Online Library
Groundwater arsenic (As) contamination is a global public health concern. The high level of
As exposure (100‐1000 μg/L or even higher) through groundwater has been frequently …

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

M Li, AE Jaffe, RE Straub, R Tao, JH Shin, Y Wang… - Nature medicine, 2016 - nature.com
Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking …

Toenails as a biomarker of exposure to arsenic: A review

AJ Signes-Pastor, E Gutiérrez-González… - Environmental …, 2021 - Elsevier
This systematic review summarizes the current evidence related to the reliability of toenail
total arsenic concentrations (thereafter “arsenic”) as a biomarker of long-term exposure …

As3MT via consuming SAM is involved in arsenic-induced nonalcoholic fatty liver disease by blocking m6A-mediated miR-142-5p maturation

H Li, L Wu, F Ye, D Wang, L Wang, W Li, Y Xu… - Science of The Total …, 2023 - Elsevier
Arsenic, a common environmental hazard, is a risk factor for nonalcoholic fatty liver disease
(NAFLD). However, the mechanism remains unclear. Here, we found that chronic exposure …