Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …

The adaptive immune system stores invaluable information about current and past immune
responses and may serve as an ultrasensitive biosensor. Given the immune system's critical …

In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …

A successful HIV vaccine eliciting broadly neutralizing antibodies (bnAbs) must overcome
the hurdle of being able to activate naive precursor B cells encoding features within their …

Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is
due to the generation of antigen-specific B cell clones with distinct specificities or the …

Immunogenomics studies have been largely limited to individuals of European ancestry,
restricting the ability to identify variation in human adaptive immune responses across …

An incomplete ascertainment of genetic variation within the highly polymorphic
immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors …

Immunoglobulins (IGs), crucial components of the adaptive immune system, are encoded by
three genomic loci. However, the complexity of the IG loci severely limits the effective use of …

Abstract Analysis of antibody repertoires by high-throughput sequencing is of major
importance in understanding adaptive immune responses. Our knowledge of variations in …

Introduction Analysis of an individual's immunoglobulin (IG) gene repertoire requires the use
of high-quality germline gene reference sets. When sets only contain alleles supported by …