EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
D Pradella, C Naro, C Sette, C Ghigna - Molecular cancer, 2017 - Springer
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
Regulation of alternative splicing through coupling with transcription and chromatin structure
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …
genetic information from DNA to proteins by expanding the coding capacity of genomes …
The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency
CY Yu, TC Li, YY Wu, CH Yeh, W Chiang… - Nature …, 2017 - nature.com
Accumulating evidence indicates that circular RNAs (circRNAs) are abundant in the human
transcriptome. However, their involvement in biological processes, including pluripotency …
transcriptome. However, their involvement in biological processes, including pluripotency …
m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
S Geula, S Moshitch-Moshkovitz, D Dominissini… - Science, 2015 - science.org
Naïve and primed pluripotent states retain distinct molecular properties, yet limited
knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N …
knowledge exists on how their state transitions are regulated. Here, we identify Mettl3, an N …
Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells
About half of the human genome consists of highly repetitive elements, most of which are
considered dispensable for human life. Here, we report that repetitive elements originating …
considered dispensable for human life. Here, we report that repetitive elements originating …
Capturing the interactome of newly transcribed RNA
We combine the labeling of newly transcribed RNAs with 5-ethynyluridine with the
characterization of bound proteins. This approach, named capture of the newly transcribed …
characterization of bound proteins. This approach, named capture of the newly transcribed …
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns
The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …
membraneless domains. However, the composition and function of many of these structures …
Multilayered control of alternative splicing regulatory networks by transcription factors
Networks of coordinated alternative splicing (AS) events play critical roles in development
and disease. However, a comprehensive knowledge of the factors that regulate these …
and disease. However, a comprehensive knowledge of the factors that regulate these …
Deterministic restriction on pluripotent state dissolution by cell-cycle pathways
During differentiation, human embryonic stem cells (hESCs) shut down the regulatory
network conferring pluripotency in a process we designated pluripotent state dissolution …
network conferring pluripotency in a process we designated pluripotent state dissolution …
[HTML][HTML] The RNA helicase DDX6 controls cellular plasticity by modulating P-body homeostasis
Post-transcriptional mechanisms have the potential to influence complex changes in gene
expression, yet their role in cell fate transitions remains largely unexplored. Here, we show …
expression, yet their role in cell fate transitions remains largely unexplored. Here, we show …