Parasympathetic signalling via muscarinic acetylcholine receptors (mAChRs) regulates
gastrointestinal smooth muscle function. In most instances, the mAChR population in smooth …

G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of
integral membrane proteins that participate in different physiological processes such as the …

Phosphorylated alpha-synuclein (p-α-syn) containing Lewy bodies (LBs) and Lewy neurites
(LNs) are neuropathological hallmarks of Parkinson's disease (PD) in the central nervous …

Intestinal inflammation alters the contractile activity of intestinal smooth muscle. Motility
disorders of the gastrointestinal tract are clinically important symptoms, because they are …

Organ–organ crosstalk is involved in homeostasis. Gastrointestinal symptoms are common
in patients with renal failure. The aim of this study was to elucidate the relationship between …

There is a rich knowledge of the enteric nervous system (ENS), especially the
neurochemical and neurophysiological properties of enteric neurons and how they …

Parasympathetic nerves control the symptoms and inflammation of allergic diseases
primarily by signaling through peripheral muscarinic receptors. Parasympathetic signaling …

Pituitary adenylate cyclase‐activating polypeptide (PACAP) plays a crucial role in immunity
and inflammation. Our aim was to obtain insight in the role of PACAP in experimental colitis …

Abstract Objective In primary Sjögren's syndrome (SS), impairment of the gastrointestinal
(GI) tract is common, and includes reduced esophageal motor function, delayed gastric …

Background Muscarinic acetylcholine receptors (MR) are involved in multiple intestinal
reflexes. The cellular localization of subtypes of MRs within enteric circuits mediating muscle …